Alnylam Pharmaceuticals Inc (ALNY)
Insider transactions
A complete record of Form 4 filings tracking every share acquisition and disposal by executives, directors, and senior officers. Filterable by date range and transaction type, the table exposes the direct market actions of those with the deepest knowledge of a company's operations — providing a factual, data-driven signal of internal conviction that complements traditional fundamental and technical analysis.
Transaction date | Executive | Executive Title | Security Type | Acquisition / Disposal | Shares | Share price |
|---|---|---|---|---|---|---|
| Sep 19, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 107 | 0 |
| Jun 1, 2026 | PYOTT, DAVID E I | Director | Common Stock | Disposal | 17 | 302.65 |
| Jun 1, 2026 | PYOTT, DAVID E I | Director | Common Stock | Disposal | 1,175 | 298.91 |
| Jun 1, 2026 | CRAVATT, BENJAMIN | Director | Stock Option (Right to Buy) | Acquisition | 4,393 | 0 |
| Jun 1, 2026 | PYOTT, DAVID E I | Director | Common Stock | Disposal | 1,222 | 299.87 |
| Jun 1, 2026 | PYOTT, DAVID E I | Director | Common Stock | Disposal | 495 | 300.72 |
| Jun 1, 2026 | PYOTT, DAVID E I | Director | Stock Option (Right to Buy) | Disposal | 3,830 | 0 |
| Jun 1, 2026 | PYOTT, DAVID E I | Director | Common Stock | Acquisition | 3,830 | 0 |
| Jun 1, 2026 | PYOTT, DAVID E I | Director | Common Stock | Disposal | 921 | 297.71 |
| May 20, 2026 | SIGAL, CHARLES ELLIOTT | Director | Common Stock | Acquisition | 671 | 0 |
| May 20, 2026 | SCHULMAN, AMY W | Director | Stock Option (Right to Buy) | Acquisition | 1,802 | 0 |
| May 20, 2026 | ARBUCKLE, STUART A | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | AUSIELLO, DENNIS A | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | SCHULMAN, AMY W | Director | Common Stock | Acquisition | 838 | 0 |
| May 20, 2026 | SIGAL, CHARLES ELLIOTT | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | REITAN, COLLEEN F | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | PYOTT, DAVID E I | Director | Common Stock | Acquisition | 671 | 0 |
| May 20, 2026 | BRANDICOURT, OLIVIER | Director | Common Stock | Acquisition | 671 | 0 |
| May 20, 2026 | AUSIELLO, DENNIS A | Director | Common Stock | Acquisition | 671 | 0 |
| May 20, 2026 | KELLOGG, PETER N | Director | Common Stock | Acquisition | 671 | 0 |
| May 20, 2026 | REITAN, COLLEEN F | Director | Common Stock | Acquisition | 671 | 0 |
| May 20, 2026 | KELLOGG, PETER N | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | PYOTT, DAVID E I | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | HAMBURG, MARGARET A | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | ARBUCKLE, STUART A | Director | Common Stock | Acquisition | 671 | 0 |
| May 20, 2026 | BRANDICOURT, OLIVIER | Director | Stock Option (Right to Buy) | Acquisition | 1,441 | 0 |
| May 20, 2026 | HAMBURG, MARGARET A | Director | Common Stock | Acquisition | 671 | 0 |
| May 13, 2026 | SCHULMAN, AMY W | Director | Stock Option (Right to Buy) | Disposal | 11,250 | 0 |
| May 13, 2026 | SCHULMAN, AMY W | Director | Common Stock | Acquisition | 11,250 | 70.2 |
| Apr 6, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 293 | 331.89 |
| Apr 6, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 829 | 330.46 |
| Apr 6, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 909 | 329.76 |
| Apr 6, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 56 | 320.14 |
| Apr 6, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 199 | 333.94 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 359 | 317.44 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 265 | 316.61 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 224 | 321.64 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 245 | 322.86 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 209 | 318.47 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 147 | 320.62 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 81 | 323.64 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 86 | 319.69 |
| Apr 2, 2026 | MCLAUGHLIN, MELISSA | Chief Human Resources Officer | Common Stock | Disposal | 8 | 325.49 |
| Mar 5, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 740 | 323.55 |
| Mar 5, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 500 | 326.08 |
| Mar 5, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 510 | 324.59 |
| Mar 5, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 654 | 322.33 |
| Mar 5, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 124 | 321.81 |
| Mar 5, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 233 | 323.25 |
| Mar 5, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 153 | 326.24 |
| Mar 5, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 148 | 324.6 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 767 | 323.84 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 767 | 323.84 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 106 | 319.03 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 102 | 320.01 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 289 | 321.82 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 208 | 325.67 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 215 | 320.81 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 272 | 324.88 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 350 | 323.01 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 129 | 320.01 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 135 | 319.03 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 274 | 320.81 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 444 | 323.01 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 368 | 321.82 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 309 | 321.82 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 291 | 324.88 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 818 | 323.84 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 350 | 323.01 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 272 | 324.88 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 208 | 325.67 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 215 | 320.81 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 106 | 319.03 |
| Mar 4, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 102 | 320.01 |
| Mar 4, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 289 | 321.82 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 973 | 323.84 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 109 | 320.01 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 28 | 320.01 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 29 | 319.03 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 57 | 325.67 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 59 | 320.81 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 114 | 319.03 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 230 | 320.81 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 223 | 325.67 |
| Mar 4, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 374 | 323.01 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 96 | 323.01 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 75 | 324.88 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 79 | 321.82 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 345 | 324.88 |
| Mar 4, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 265 | 325.67 |
| Mar 4, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 210 | 323.84 |
| Mar 3, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 463 | 321.5 |
| Mar 3, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 317 | 319.06 |
| Mar 3, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 355 | 316.74 |
| Mar 3, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 282 | 318.62 |
| Mar 3, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 359 | 321.58 |
| Mar 3, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 289 | 316.55 |
| Mar 3, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 722 | 320.51 |
| Mar 3, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 640 | 320.48 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Acquisition | 4,769 | 0 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,098 | 325.63 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Stock Option (right to buy) | Acquisition | 8,105 | 0 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Stock Option (right to buy) | Acquisition | 10,480 | 0 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 13,844 | 0 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 81 | 330.85 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 90 | 324.65 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 47 | 323.62 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 37 | 332.64 |
| Mar 2, 2026 | SUPRAN, BRYAN | EVP, CLO and Secretary | Common Stock | Acquisition | 1,539 | 0 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 37 | 332.64 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 47 | 323.62 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 81 | 330.85 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 90 | 324.65 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 94 | 331.93 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 100 | 328.71 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 170 | 329.71 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 392 | 326.81 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 258 | 325.63 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Stock Option (right to buy) | Acquisition | 10,480 | 0 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 454 | 327.67 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 53 | 332.64 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 329 | 327.67 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 65 | 323.62 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 112 | 330.85 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 124 | 324.65 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 138 | 328.71 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 129 | 331.93 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 234 | 329.71 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 356 | 325.63 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 399 | 331.93 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 722 | 329.71 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Acquisition | 4,769 | 0 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 42 | 332.64 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 50 | 323.62 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 107 | 328.71 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 101 | 331.93 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 97 | 324.65 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 87 | 330.85 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 182 | 329.71 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Stock Price Performance Stock Unit | Acquisition | 110,746 | 0 |
| Mar 2, 2026 | SUPRAN, BRYAN | EVP, CLO and Secretary | Stock Option (right to buy) | Acquisition | 3,381 | 0 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,669 | 326.81 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Stock Option (right to buy) | Acquisition | 10,480 | 0 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 329 | 327.67 |
| Mar 2, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Acquisition | 3,688 | 0 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,399 | 327.67 |
| Mar 2, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 541 | 326.81 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Stock Option (right to buy) | Acquisition | 30,425 | 0 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 392 | 326.81 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 258 | 325.63 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 170 | 329.71 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 100 | 328.71 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 94 | 331.93 |
| Mar 2, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Acquisition | 4,769 | 0 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 200 | 323.62 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 160 | 332.64 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 382 | 324.65 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 346 | 330.85 |
| Mar 2, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 424 | 328.71 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 277 | 325.63 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 421 | 326.81 |
| Mar 2, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 353 | 327.67 |
| Feb 27, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 1,159 | 331.49 |
| Feb 27, 2026 | GARG, PUSHKAL | EVP Chief R&D | Restricted Stock Units | Disposal | 1,908 | 0 |
| Feb 27, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 5,921 | 0 |
| Feb 27, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 942 | 332.48 |
| Feb 27, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 2,259 | 330.73 |
| Feb 27, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Acquisition | 1,908 | 0 |
| Feb 27, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Acquisition | 1,666 | 0 |
| Feb 27, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Acquisition | 1,908 | 0 |
| Feb 27, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Restricted Stock Units | Disposal | 1,666 | 0 |
| Feb 27, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Restricted Stock Units | Disposal | 5,921 | 0 |
| Feb 27, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 127 | 328.92 |
| Feb 27, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 140 | 334.39 |
| Feb 27, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Restricted Stock Units | Disposal | 1,908 | 0 |
| Feb 23, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Acquisition | 158 | 0 |
| Feb 17, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 2,041 | 331.961 |
| Feb 13, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 2,242 | 310.081 |
| Feb 13, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 1,959 | 310.081 |
| Feb 13, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 6,958 | 310.081 |
| Feb 13, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 2,242 | 310.081 |
| Feb 13, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 1,959 | 310.081 |
| Feb 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Acquisition | 4,000 | 0 |
| Feb 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 14,209 | 0 |
| Feb 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Acquisition | 4,579 | 0 |
| Feb 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Acquisition | 4,579 | 0 |
| Feb 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Acquisition | 4,000 | 0 |
| Jan 13, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 485 | 371.24 |
| Jan 13, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 562 | 368.76 |
| Jan 13, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 122 | 374.33 |
| Jan 13, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 197 | 367.52 |
| Jan 13, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 644 | 370 |
| Jan 13, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 280 | 372.93 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 36 | 370.87 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 34 | 375.65 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 27 | 377.82 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 25 | 374.44 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 87 | 363.55 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 76 | 367.4 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 78 | 355.16 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 76 | 367.4 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 72 | 353.95 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 73 | 369.48 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 181 | 361.45 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 176 | 357.17 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 170 | 368.62 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 156 | 359.14 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 135 | 362.38 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 92 | 366.41 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 284 | 360.22 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 226 | 358.18 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 6 | 372.46 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 537 | 359.14 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,395 | 365.56 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,259 | 364.83 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 2 | 372.46 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 14 | 374.44 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 15 | 377.82 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 19 | 375.65 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 19 | 370.87 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 42 | 355.16 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 40 | 369.48 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 41 | 367.4 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 41 | 367.4 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 39 | 353.95 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 50 | 366.41 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 47 | 363.55 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 85 | 359.14 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 73 | 362.38 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 96 | 357.17 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 98 | 361.45 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 92 | 368.62 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 123 | 358.18 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 155 | 360.22 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 199 | 364.83 |
| Jan 12, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 220 | 365.56 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 118 | 370.87 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 118 | 375.65 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 94 | 377.82 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 88 | 374.44 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 253 | 369.48 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 247 | 353.95 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 464 | 362.38 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 316 | 366.41 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 980 | 360.22 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 624 | 361.45 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 584 | 368.62 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 21 | 372.46 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 50 | 366.41 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 73 | 362.38 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 92 | 368.62 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 98 | 361.45 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 96 | 357.17 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 85 | 359.14 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 39 | 353.95 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 40 | 369.48 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 41 | 367.4 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 41 | 356.09 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 47 | 363.55 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 42 | 355.16 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 220 | 365.56 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 199 | 364.83 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 123 | 358.18 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 155 | 360.22 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 2 | 372.46 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 14 | 374.44 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 15 | 377.82 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 19 | 375.65 |
| Jan 12, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 19 | 375.65 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 405 | 365.56 |
| Jan 12, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 365 | 364.83 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 607 | 357.17 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 39 | 353.95 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 42 | 355.16 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 40 | 369.48 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 41 | 356.09 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 41 | 356.09 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 47 | 363.55 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 50 | 366.41 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 14 | 374.44 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 15 | 377.82 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 19 | 375.65 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 18 | 370.87 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 123 | 358.18 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 155 | 360.22 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 199 | 364.83 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 220 | 365.56 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 73 | 362.38 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 85 | 359.14 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 92 | 368.62 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 98 | 361.45 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 96 | 357.17 |
| Jan 12, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 3 | 372.46 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 261 | 367.4 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 263 | 356.09 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 301 | 363.55 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 269 | 355.16 |
| Jan 12, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 778 | 358.18 |
| Jan 11, 2026 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Acquisition | 3,800 | 0 |
| Jan 11, 2026 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 19,003 | 0 |
| Jan 11, 2026 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Acquisition | 3,800 | 0 |
| Jan 11, 2026 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Acquisition | 3,800 | 0 |
| Jan 11, 2026 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Acquisition | 6,193 | 0 |
| Jan 5, 2026 | ARBUCKLE, STUART A | Director | Stock Option (right to buy) | Acquisition | 3,279 | 0 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 839 | 119.13 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 847 | 118.05 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 659 | 151.59 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Stock Option (right to buy) | Disposal | 2,352 | 0 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Stock Option (right to buy) | Disposal | 839 | 0 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Stock Option (right to buy) | Disposal | 847 | 0 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Stock Option (right to buy) | Disposal | 659 | 0 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,121 | 445.12 |
| Nov 26, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 2,352 | 85 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Stock Option (right to buy) | Disposal | 8,161 | 0 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 794 | 458.41 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 323 | 461.96 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 622 | 459.89 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 295 | 463.08 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 8,168 | 449 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 707 | 460.84 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Acquisition | 8,161 | 119.13 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 364 | 456.25 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 368 | 455.24 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 262 | 457.39 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 96 | 450.09 |
| Nov 17, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 129 | 451.51 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 195 | 454.69 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 10,000 | 119.13 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,599 | 452.85 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Performance Stock Option 2017 (right to buy) | Disposal | 10,000 | 0 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,702 | 451.94 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 2,218 | 450.69 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,477 | 450.02 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 654 | 447.73 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 261 | 456.03 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,013 | 448.76 |
| Nov 13, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 881 | 453.99 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 711 | 448.07 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 430 | 458.42 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 604 | 457.71 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,960 | 454.84 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,069 | 453.52 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Performance Stock Option 2016 (right to buy) | Disposal | 650 | 0 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,255 | 451.16 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 3,406 | 455.56 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 650 | 42.22 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 453 | 450.17 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 15,000 | 119.13 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 2,132 | 449.15 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,210 | 452.43 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 2,420 | 456.64 |
| Nov 12, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Performance Stock Option 2017 (right to buy) | Disposal | 15,000 | 0 |
| Oct 3, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 417 | 453.51 |
| Oct 3, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 898 | 451.76 |
| Oct 3, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 682 | 449.99 |
| Oct 3, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 810 | 450.63 |
| Oct 3, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 215 | 454.37 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 541 | 450.81 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 741 | 454.84 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,642 | 450.81 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 4 | 457.64 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 73 | 447.92 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 95 | 455.82 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 191 | 457.43 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 150 | 446.53 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 234 | 448.77 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 324 | 449.79 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 428 | 453.77 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 432 | 451.86 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 704 | 450.81 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 449 | 450.81 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 273 | 453.77 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 555 | 452.69 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 1 | 457.64 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 159 | 451.86 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 157 | 453.77 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 119 | 449.79 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 117 | 454.84 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 86 | 448.77 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 55 | 446.53 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 70 | 457.43 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 27 | 447.92 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 35 | 455.82 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 260 | 450.81 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 221 | 455.82 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 171 | 447.92 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 446 | 457.43 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 350 | 446.53 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 548 | 448.77 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 869 | 452.69 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 329 | 453.77 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 9 | 457.64 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 2,029 | 452.69 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 999 | 453.77 |
| Oct 2, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Disposal | 317 | 454.84 |
| Oct 2, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Disposal | 319 | 452.69 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 3 | 457.64 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 47 | 447.92 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 668 | 452.69 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 758 | 449.79 |
| Oct 2, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Disposal | 1,010 | 451.86 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 96 | 446.53 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 60 | 455.82 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 203 | 454.84 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 207 | 449.79 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 122 | 457.43 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 150 | 448.77 |
| Oct 2, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Disposal | 276 | 451.86 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 3 | 457.64 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 56 | 447.92 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 73 | 455.82 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 115 | 446.53 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 180 | 448.77 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 147 | 457.43 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 249 | 449.79 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 244 | 454.84 |
| Oct 2, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Disposal | 332 | 451.86 |
| Oct 1, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Acquisition | 2,851 | 0 |
| Oct 1, 2025 | SUPRAN, BRYAN | EVP, CLO and Secretary | Common Stock | Acquisition | 13,026 | 0 |
| Oct 1, 2025 | FITZGERALD, KEVIN JOSEPH | CSO & EVP, Head of Research | Common Stock | Acquisition | 2,102 | 0 |
| Oct 1, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Acquisition | 3,108 | 0 |
| Oct 1, 2025 | GARG, PUSHKAL | EVP Chief R&D | Common Stock | Acquisition | 2,851 | 0 |
| Oct 1, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 14,252 | 0 |
| Oct 1, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Acquisition | 4,644 | 0 |
| Oct 1, 2025 | POULTON, JEFFREY V. | EVP, Chief Financial Officer | Common Stock | Acquisition | 3,108 | 0 |
| Oct 1, 2025 | GREENSTREET, YVONNE | Director, Chief Executive Officer | Common Stock | Acquisition | 3,860 | 0 |
| Oct 1, 2025 | TANGULER, TOLGA | EVP, Chief Commercial Officer | Common Stock | Acquisition | 2,851 | 0 |