Ionis Pharmaceuticals Inc (IONS)
Insider transactions
A complete record of Form 4 filings tracking every share acquisition and disposal by executives, directors, and senior officers. Filterable by date range and transaction type, the table exposes the direct market actions of those with the deepest knowledge of a company's operations — providing a factual, data-driven signal of internal conviction that complements traditional fundamental and technical analysis.
Transaction date | Executive | Executive Title | Security Type | Acquisition / Disposal | Shares | Share price |
|---|---|---|---|---|---|---|
| Aug 31, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 63 | 51.306 |
| Aug 31, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 98 | 51.306 |
| Aug 31, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Acquisition | 58 | 51.306 |
| Aug 31, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 110 | 51.306 |
| Jul 31, 2026 | HAYDEN, MICHAEL R | Director | Common Stock | Acquisition | 5,000 | 51.6 |
| Jul 30, 2026 | HAYDEN, MICHAEL R | Director | Common Stock | Acquisition | 15,000 | 53.38 |
| Jul 15, 2026 | HERMAN, JOAN E | Director | Common Stock | Acquisition | 5,220 | 0 |
| Jul 15, 2026 | BERTHELSEN, SPENCER R | Director | Restricted Stock Unit | Disposal | 5,220 | 0 |
| Jul 15, 2026 | REIKES, PETER N | Director | Restricted Stock Unit | Acquisition | 3,399 | 0 |
| Jul 15, 2026 | HANTSON, LUDWIG | Director | Restricted Stock Unit | Acquisition | 3,399 | 0 |
| Jul 15, 2026 | HERMAN, JOAN E | Director | Restricted Stock Unit | Disposal | 5,220 | 0 |
| Jul 15, 2026 | BERTHELSEN, SPENCER R | Director | Common Stock | Acquisition | 5,220 | 0 |
| Jul 7, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 15,000 | 0 |
| Jul 7, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 15,000 | 85.462 |
| Jul 7, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 5,536 | 83.579 |
| Jul 7, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Disposal | 362 | 84.3 |
| Jul 7, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Restricted Stock Unit | Disposal | 15,000 | 0 |
| Jul 7, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Disposal | 10,111 | 85.416 |
| Jul 7, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Acquisition | 10,111 | 47.11 |
| Jul 7, 2026 | DIAZ, ALLENE M. | Director | Non-Qualified Stock Option (right to buy) | Disposal | 10,111 | 0 |
| Jul 1, 2026 | BERTHELSEN, SPENCER R | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 5,369 | 0 |
| Jul 1, 2026 | HAYDEN, MICHAEL R | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 5,369 | 0 |
| Jul 1, 2026 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Disposal | 11,518 | 0 |
| Jul 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 11,419 | 79.039 |
| Jul 1, 2026 | HERMAN, JOAN E | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 5,369 | 0 |
| Jul 1, 2026 | LOSCALZO, JOSEPH | Director | Restricted Stock Unit | Acquisition | 2,301 | 0 |
| Jul 1, 2026 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 5,369 | 0 |
| Jul 1, 2026 | YANG, MICHAEL J. | Director | Restricted Stock Unit | Acquisition | 2,301 | 0 |
| Jul 1, 2026 | HAYDEN, MICHAEL R | Director | Restricted Stock Unit | Acquisition | 2,301 | 0 |
| Jul 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 99 | 79.45 |
| Jul 1, 2026 | DIAZ, ALLENE M. | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 5,369 | 0 |
| Jul 1, 2026 | HERMAN, JOAN E | Director | Restricted Stock Unit | Acquisition | 2,301 | 0 |
| Jul 1, 2026 | BERTHELSEN, SPENCER R | Director | Restricted Stock Unit | Acquisition | 2,301 | 0 |
| Jul 1, 2026 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 5,369 | 0 |
| Jul 1, 2026 | KLEIN, JOSEPH III | Director | Restricted Stock Unit | Acquisition | 2,301 | 0 |
| Jul 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Acquisition | 11,518 | 39.94 |
| Jul 1, 2026 | DIAZ, ALLENE M. | Director | Restricted Stock Unit | Acquisition | 2,301 | 0 |
| Jul 1, 2026 | YANG, MICHAEL J. | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 5,369 | 0 |
| Jun 26, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 50,000 | 56.78 |
| Jun 26, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 50,000 | 80.59 |
| Jun 26, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 50,000 | 0 |
| Jun 26, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 3,069 | 80 |
| Jun 26, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 5,635 | 80.16 |
| Jun 26, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Disposal | 1,769 | 0 |
| Jun 26, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 1,769 | 32.6 |
| Jun 26, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Non-Qualified Stock Option (right to buy) | Disposal | 26,000 | 0 |
| Jun 26, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Disposal | 3,866 | 0 |
| Jun 26, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Common Stock | Disposal | 26,000 | 81.046 |
| Jun 26, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 3,866 | 56.78 |
| Jun 26, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Common Stock | Acquisition | 26,000 | 60.89 |
| Jun 25, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 21,072 | 78.49 |
| Jun 25, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 21,072 | 32.6 |
| Jun 25, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 21,072 | 0 |
| Jun 25, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 10,602 | 79.182 |
| Jun 24, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 14,565 | 0 |
| Jun 24, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 14,565 | 78.413 |
| Jun 24, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 14,565 | 32.6 |
| Jun 15, 2026 | BERTHELSEN, SPENCER R | Director | Common Stock | Disposal | 8,000 | 73.49 |
| Jun 15, 2026 | BERTHELSEN, SPENCER R | Director | Common Stock | Acquisition | 8,000 | 24.42 |
| Jun 15, 2026 | BERTHELSEN, SPENCER R | Director | Non-Qualified Stock Option (right to buy) | Disposal | 8,000 | 0 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Acquisition | 12,000 | 32.6 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 21,000 | 0 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Disposal | 19,842 | 74.05 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Acquisition | 21,000 | 60.89 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Disposal | 41,004 | 73.093 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 12,000 | 0 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 7,951 | 0 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 19,895 | 0 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Acquisition | 19,895 | 56.78 |
| Jun 12, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Acquisition | 7,951 | 60.89 |
| Jun 4, 2026 | HANTSON, LUDWIG | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 10,753 | 0 |
| Jun 4, 2026 | REIKES, PETER N | Director | Non-Qualified Stock Option (right to buy) | Acquisition | 10,753 | 0 |
| Jun 1, 2026 | BERTHELSEN, SPENCER R | Director | Common Stock | Disposal | 8,000 | 75.67 |
| Jun 1, 2026 | BERTHELSEN, SPENCER R | Director | Common Stock | Acquisition | 8,000 | 24.42 |
| Jun 1, 2026 | BERTHELSEN, SPENCER R | Director | Non-Qualified Stock Option (right to buy) | Disposal | 8,000 | 0 |
| May 14, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 3,220 | 0 |
| May 14, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 3,220 | 32.6 |
| May 14, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 3,220 | 78.679 |
| May 13, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 1,316 | 0 |
| May 13, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 1,316 | 78.013 |
| May 13, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 1,316 | 32.6 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Disposal | 17,781 | 75.583 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Disposal | 10,968 | 0 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Disposal | 10,321 | 0 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 16,000 | 64.8 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 16,000 | 42.88 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Disposal | 59,508 | 74.902 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Disposal | 16,000 | 0 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 10,968 | 38.06 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 12,000 | 60.2 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 12,000 | 40.05 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 10,321 | 41.08 |
| May 4, 2026 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Disposal | 12,000 | 0 |
| May 1, 2026 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Disposal | 10,111 | 0 |
| May 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 1,431 | 74.447 |
| May 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Acquisition | 10,111 | 47.11 |
| May 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 8,680 | 73.353 |
| Apr 28, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 1,626 | 71.788 |
| Apr 16, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Disposal | 4,902 | 75.171 |
| Apr 16, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Disposal | 973 | 75.042 |
| Apr 16, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 5,619 | 74.56 |
| Apr 15, 2026 | PARSHALL, B LYNNE | Director | Common Stock | Disposal | 534 | 76.97 |
| Apr 15, 2026 | PARSHALL, B LYNNE | Director | Common Stock | Disposal | 4,466 | 76.19 |
| Apr 15, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Acquisition | 12,226 | 0 |
| Apr 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Restricted Stock Unit | Disposal | 10,837 | 0 |
| Apr 15, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Restricted Stock Unit | Disposal | 1,875 | 0 |
| Apr 15, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Restricted Stock Unit | Disposal | 12,226 | 0 |
| Apr 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 10,837 | 0 |
| Apr 15, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Acquisition | 1,875 | 0 |
| Apr 2, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 6,193 | 74.054 |
| Apr 1, 2026 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Disposal | 12,000 | 0 |
| Apr 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Acquisition | 10,321 | 41.08 |
| Apr 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 20,105 | 75.503 |
| Apr 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Acquisition | 12,000 | 38.06 |
| Apr 1, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 2,216 | 75.954 |
| Apr 1, 2026 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Disposal | 10,321 | 0 |
| Mar 19, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Common Stock | Disposal | 5,812 | 70.972 |
| Mar 17, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Disposal | 10,172 | 73.207 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Disposal | 9,440 | 72.765 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Acquisition | 20,541 | 37.58 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Disposal | 205,608 | 72.381 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Non-Qualified Stock Option (right to buy) | Disposal | 60,299 | 0 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Acquisition | 33,118 | 32.6 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Non-Qualified Stock Option (right to buy) | Disposal | 61,041 | 0 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Acquisition | 60,299 | 60.89 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Acquisition | 61,041 | 56.78 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Non-Qualified Stock Option (right to buy) | Disposal | 33,118 | 0 |
| Mar 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Non-Qualified Stock Option (right to buy) | Disposal | 20,541 | 0 |
| Mar 10, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Non-Qualified Stock Option (right to buy) | Disposal | 4,675 | 0 |
| Mar 10, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Disposal | 16,086 | 76.3 |
| Mar 10, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 17,591 | 76.341 |
| Mar 10, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 16,512 | 75.475 |
| Mar 10, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Non-Qualified Stock Option (right to buy) | Disposal | 32,602 | 0 |
| Mar 10, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Acquisition | 4,675 | 34.69 |
| Mar 10, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 34,103 | 0 |
| Mar 10, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Disposal | 21,191 | 75.502 |
| Mar 10, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Acquisition | 32,602 | 46.1 |
| Mar 10, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 34,103 | 60.89 |
| Mar 9, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 10,148 | 75.253 |
| Mar 9, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 73,529 | 60.89 |
| Mar 9, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 40,822 | 60.89 |
| Mar 9, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 40,822 | 0 |
| Mar 9, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 1,684 | 75.583 |
| Mar 9, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Disposal | 73,529 | 0 |
| Mar 9, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 117,604 | 75.258 |
| Mar 9, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 7,382 | 74.111 |
| Mar 4, 2026 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Disposal | 200 | 0 |
| Mar 4, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 201 | 80 |
| Mar 4, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 238 | 80 |
| Mar 4, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 238 | 56.78 |
| Mar 4, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 201 | 32.6 |
| Mar 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 200 | 38.06 |
| Mar 4, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Disposal | 200 | 80 |
| Mar 4, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Disposal | 238 | 0 |
| Mar 4, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Disposal | 201 | 0 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Disposal | 1,005 | 80.799 |
| Mar 3, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Disposal | 820 | 0 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 6,951 | 0 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 3,760 | 40.85 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Disposal | 14,608 | 79.875 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Acquisition | 10,321 | 41.08 |
| Mar 3, 2026 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Disposal | 4,000 | 0 |
| Mar 3, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 71,600 | 79.099 |
| Mar 3, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 879 | 32.6 |
| Mar 3, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Non-Qualified Stock Option (right to buy) | Disposal | 16,463 | 0 |
| Mar 3, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 802 | 80.762 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 3,510 | 0 |
| Mar 3, 2026 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Disposal | 12,000 | 0 |
| Mar 3, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Non-Qualified Stock Option (right to buy) | Disposal | 48,626 | 0 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Non-Qualified Stock Option (right to buy) | Disposal | 18,000 | 0 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 385 | 52.87 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 5,500 | 34.69 |
| Mar 3, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 832 | 38.06 |
| Mar 3, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 6,794 | 79.995 |
| Mar 3, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 12,687 | 79.878 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 3,760 | 0 |
| Mar 3, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 36 | 81.01 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 6,951 | 32.6 |
| Mar 3, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 4,096 | 79.36 |
| Mar 3, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Acquisition | 4,000 | 42.88 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Acquisition | 12,000 | 38.06 |
| Mar 3, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 1,012 | 80.818 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 5,500 | 0 |
| Mar 3, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 13,526 | 79.174 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Disposal | 39,265 | 79.114 |
| Mar 3, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 820 | 56.78 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 3,510 | 37.58 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Common Stock | Acquisition | 18,000 | 40.05 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Non-Qualified Stock Option (right to buy) | Disposal | 10,321 | 0 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 5,030 | 79.999 |
| Mar 3, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 48,626 | 60.89 |
| Mar 3, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 2,088 | 80.408 |
| Mar 3, 2026 | KLEIN, JOSEPH III | Director | Common Stock | Acquisition | 12,000 | 40.05 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 755 | 80.837 |
| Mar 3, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 16,463 | 32.6 |
| Mar 3, 2026 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Disposal | 832 | 0 |
| Mar 3, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Disposal | 879 | 0 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 14,321 | 79.115 |
| Mar 3, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 385 | 0 |
| Mar 3, 2026 | LOSCALZO, JOSEPH | Director | Common Stock | Disposal | 832 | 80.328 |
| Mar 3, 2026 | DIAZ, ALLENE M. | Director | Non-Qualified Stock Option (right to buy) | Disposal | 12,000 | 0 |
| Feb 27, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 484 | 48.867 |
| Feb 27, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 256 | 48.867 |
| Feb 27, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Acquisition | 351 | 48.867 |
| Feb 27, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 376 | 48.867 |
| Feb 27, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 261 | 48.867 |
| Feb 13, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 9,435 | 81.559 |
| Feb 13, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 6,207 | 82.069 |
| Feb 11, 2026 | PARSHALL, B LYNNE | Director | Common Stock | Disposal | 5,000 | 82.718 |
| Feb 6, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 29,430 | 85.791 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 20,000 | 82.599 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Non-Qualified Stock Option (right to buy) | Disposal | 48,626 | 0 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 48,626 | 60.89 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 48,626 | 83.028 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Non-Qualified Stock Option (right to buy) | Disposal | 16,463 | 0 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 16,463 | 32.6 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 16,463 | 83.028 |
| Feb 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 0 | 0 |
| Jan 30, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Disposal | 6,988 | 83.243 |
| Jan 30, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 5,885 | 82.947 |
| Jan 30, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Common Stock | Disposal | 6,179 | 83.449 |
| Jan 30, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 6,179 | 83.534 |
| Jan 30, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Disposal | 6,179 | 83.031 |
| Jan 30, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 5,296 | 82.962 |
| Jan 30, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 62,970 | 82.722 |
| Jan 30, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 6,179 | 82.934 |
| Jan 29, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Acquisition | 11,991 | 0 |
| Jan 29, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 10,278 | 0 |
| Jan 29, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 11,991 | 0 |
| Jan 29, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 11,421 | 0 |
| Jan 29, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Acquisition | 13,562 | 0 |
| Jan 29, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Common Stock | Acquisition | 11,991 | 0 |
| Jan 29, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 11,991 | 0 |
| Jan 29, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 122,214 | 0 |
| Jan 22, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 3,977 | 81.34 |
| Jan 16, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 49 | 75.97 |
| Jan 16, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Disposal | 8,480 | 75.11 |
| Jan 16, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 9,191 | 75.84 |
| Jan 16, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Disposal | 8,977 | 75.15 |
| Jan 16, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 6,907 | 75.75 |
| Jan 16, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 9,884 | 75.34 |
| Jan 16, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Disposal | 12,922 | 75.22 |
| Jan 16, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 1,149 | 75.78 |
| Jan 16, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 8,353 | 75.95 |
| Jan 16, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Disposal | 1,823 | 75.96 |
| Jan 16, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 44,034 | 74.82 |
| Jan 16, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Disposal | 4,141 | 75.66 |
| Jan 16, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Common Stock | Disposal | 9,302 | 75.59 |
| Jan 15, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Restricted Stock Unit | Disposal | 21,685 | 0 |
| Jan 15, 2026 | SWAYZE, ERIC | EVP Research | Restricted Stock Unit | Disposal | 111 | 0 |
| Jan 15, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Restricted Stock Unit | Disposal | 89,145 | 0 |
| Jan 15, 2026 | SWAYZE, ERIC | EVP Research | Restricted Stock Unit | Disposal | 21,366 | 0 |
| Jan 15, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Common Stock | Acquisition | 11,119 | 0 |
| Jan 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Restricted Stock Unit | Acquisition | 3,900 | 0 |
| Jan 15, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Restricted Stock Unit | Disposal | 21,055 | 0 |
| Jan 15, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Restricted Stock Unit | Acquisition | 11,250 | 0 |
| Jan 15, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Acquisition | 20,089 | 0 |
| Jan 15, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Common Stock | Acquisition | 7,013 | 0 |
| Jan 15, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 111 | 0 |
| Jan 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Restricted Stock Unit | Disposal | 17,377 | 0 |
| Jan 15, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | SWAYZE, ERIC | EVP Research | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 21,473 | 0 |
| Jan 15, 2026 | YANG, MICHAEL J. | Director | Restricted Stock Unit | Disposal | 1,930 | 0 |
| Jan 15, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Restricted Stock Unit | Disposal | 11,119 | 0 |
| Jan 15, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Performance Restricted Stock Units | Acquisition | 34,360 | 0 |
| Jan 15, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Restricted Stock Unit | Acquisition | 42,705 | 0 |
| Jan 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Restricted Stock Unit | Disposal | 2,850 | 0 |
| Jan 15, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Restricted Stock Unit | Disposal | 21,473 | 0 |
| Jan 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Restricted Stock Unit | Disposal | 17,037 | 0 |
| Jan 15, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Acquisition | 89,145 | 0 |
| Jan 15, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Restricted Stock Unit | Acquisition | 12,885 | 0 |
| Jan 15, 2026 | YANG, MICHAEL J. | Director | Common Stock | Acquisition | 1,930 | 0 |
| Jan 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 17,037 | 0 |
| Jan 15, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Common Stock | Acquisition | 21,055 | 0 |
| Jan 15, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Performance Restricted Stock Units | Acquisition | 113,880 | 0 |
| Jan 15, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Restricted Stock Unit | Acquisition | 9,675 | 0 |
| Jan 15, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 2,850 | 0 |
| Jan 15, 2026 | SWAYZE, ERIC | EVP Research | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Acquisition | 28,729 | 0 |
| Jan 15, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Restricted Stock Unit | Acquisition | 13,650 | 0 |
| Jan 15, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 21,366 | 0 |
| Jan 15, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 17,377 | 0 |
| Jan 15, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Restricted Stock Unit | Disposal | 7,013 | 0 |
| Jan 15, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Common Stock | Acquisition | 21,685 | 0 |
| Jan 15, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Restricted Stock Unit | Disposal | 20,089 | 0 |
| Jan 15, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Performance Restricted Stock Units | Acquisition | 25,800 | 0 |
| Jan 15, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Restricted Stock Unit | Disposal | 28,729 | 0 |
| Jan 15, 2026 | SWAYZE, ERIC | EVP Research | Restricted Stock Unit | Acquisition | 225 | 0 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 9,264 | 84.62 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 9,264 | 52.87 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 2,101 | 85.36 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 3,829 | 84.62 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 3,829 | 37.58 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 3,460 | 0 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 2,101 | 32.6 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 3,460 | 84.62 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 25,545 | 0 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 3,460 | 32.6 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 25,545 | 85.36 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 25,545 | 56.78 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 2,101 | 0 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 3,829 | 0 |
| Jan 7, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 9,264 | 0 |
| Jan 2, 2026 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Non-Qualified Stock Option (right to buy) | Acquisition | 150 | 0 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 5,125 | 60.89 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 5,125 | 78.57 |
| Jan 2, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Acquisition | 9,100 | 0 |
| Jan 2, 2026 | BENNETT, C FRANK | EVP, Chief Scientific Officer | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Non-Qualified Stock Option (right to buy) | Disposal | 5,125 | 0 |
| Jan 2, 2026 | KORDASIEWICZ, HOLLY B. | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Acquisition | 7,500 | 0 |
| Jan 2, 2026 | JENNE, KYLE | EVP, Chf GL Pdt Str Ofcr | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Non-Qualified Stock Option (right to buy) | Disposal | 18,338 | 0 |
| Jan 2, 2026 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Non-Qualified Stock Option (right to buy) | Acquisition | 25,770 | 0 |
| Jan 2, 2026 | MONIA, BRETT P | Director, Chief Executive Officer | Non-Qualified Stock Option (right to buy) | Acquisition | 85,410 | 0 |
| Jan 2, 2026 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | SCHNEIDER, EUGENE | EVP, Chf Clinical Develop Ofcr | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Acquisition | 19,350 | 0 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 18,338 | 60.89 |
| Jan 2, 2026 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Acquisition | 2,600 | 0 |
| Jan 2, 2026 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 18,338 | 79.27 |
| Dec 1, 2025 | WENDER, JOSEPH H | Director | Common Stock | Disposal | 7,429 | 81.234 |
| Dec 1, 2025 | WENDER, JOSEPH H | Director | Common Stock | Disposal | 20,571 | 80.665 |
| Nov 25, 2025 | KLEIN, JOSEPH III | Director | Common Stock | Acquisition | 4,000 | 0 |
| Nov 25, 2025 | KLEIN, JOSEPH III | Director | Common Stock | Disposal | 4,000 | 80 |
| Nov 25, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 16,777 | 0 |
| Nov 25, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 16,777 | 53.77 |
| Nov 25, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 16,777 | 80.911 |
| Nov 25, 2025 | KLEIN, JOSEPH III | Director | Non-Qualified Stock Option (right to buy) | Disposal | 4,000 | 0 |
| Nov 19, 2025 | HERMAN, JOAN E | Director | Non-Qualified Stock Option (right to buy) | Disposal | 12,000 | 0 |
| Nov 19, 2025 | HERMAN, JOAN E | Director | Non-Qualified Stock Option (right to buy) | Disposal | 32,000 | 0 |
| Nov 19, 2025 | HERMAN, JOAN E | Director | Common Stock | Acquisition | 32,000 | 63.9 |
| Nov 19, 2025 | HERMAN, JOAN E | Director | Common Stock | Disposal | 32,000 | 72.133 |
| Nov 19, 2025 | HERMAN, JOAN E | Director | Common Stock | Acquisition | 12,000 | 40.05 |
| Nov 19, 2025 | HERMAN, JOAN E | Director | Common Stock | Disposal | 12,000 | 72.133 |
| Nov 18, 2025 | WENDER, JOSEPH H | Director | Common Stock | Acquisition | 16,000 | 24.42 |
| Nov 18, 2025 | WENDER, JOSEPH H | Director | Non-Qualified Stock Option (right to buy) | Disposal | 16,000 | 0 |
| Nov 6, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 14,738 | 76.097 |
| Nov 6, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 14,738 | 56.78 |
| Nov 6, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 18,300 | 0 |
| Nov 6, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 14,738 | 0 |
| Nov 6, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 18,300 | 75.421 |
| Nov 6, 2025 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Disposal | 8,000 | 76.172 |
| Nov 6, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 18,300 | 60.89 |
| Nov 5, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 800 | 56.78 |
| Nov 5, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 800 | 75.01 |
| Nov 5, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 801 | 0 |
| Nov 5, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 801 | 60.89 |
| Nov 5, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 801 | 75.01 |
| Nov 5, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 800 | 0 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 775 | 0 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 905 | 0 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 775 | 75.054 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 775 | 60.89 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 775 | 60.89 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 905 | 75.054 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 905 | 56.78 |
| Nov 3, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 905 | 56.78 |
| Oct 31, 2025 | WENDER, JOSEPH H | Director | Common Stock | Disposal | 11,200 | 75.159 |
| Oct 31, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 34,585 | 0 |
| Oct 31, 2025 | LOSCALZO, JOSEPH | Director | Common Stock | Disposal | 16,000 | 75.104 |
| Oct 31, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 34,585 | 60.89 |
| Oct 31, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 34,585 | 75.108 |
| Oct 31, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 34,664 | 0 |
| Oct 31, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 20,000 | 75.108 |
| Oct 31, 2025 | LOSCALZO, JOSEPH | Director | Non-Qualified Stock Option (right to buy) | Disposal | 16,000 | 0 |
| Oct 31, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 34,664 | 75.108 |
| Oct 31, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 34,664 | 56.78 |
| Oct 31, 2025 | LOSCALZO, JOSEPH | Director | Common Stock | Acquisition | 16,000 | 52.22 |
| Oct 30, 2025 | WENDER, JOSEPH H | Director | Common Stock | Disposal | 5,975 | 73.85 |
| Oct 30, 2025 | WENDER, JOSEPH H | Director | Common Stock | Disposal | 8,341 | 73.16 |
| Oct 30, 2025 | WENDER, JOSEPH H | Director | Common Stock | Disposal | 2,484 | 72.19 |
| Oct 16, 2025 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 53 | 73.621 |
| Oct 16, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 1,263 | 73.621 |
| Oct 15, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 2,820 | 0 |
| Oct 15, 2025 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Disposal | 12,425 | 72.225 |
| Oct 15, 2025 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Acquisition | 12,425 | 53.77 |
| Oct 15, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Disposal | 6,000 | 72.942 |
| Oct 15, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Common Stock | Acquisition | 6,000 | 48.51 |
| Oct 15, 2025 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 125 | 0 |
| Oct 15, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Restricted Stock Unit | Disposal | 2,820 | 0 |
| Oct 15, 2025 | SWAYZE, ERIC | EVP Research | Restricted Stock Unit | Disposal | 125 | 0 |
| Oct 15, 2025 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Non-Qualified Stock Option (right to buy) | Disposal | 12,425 | 0 |
| Oct 15, 2025 | PARSHALL, B LYNNE | Director | Common Stock | Disposal | 5,000 | 71.744 |
| Oct 15, 2025 | DEVERS, SHANNON L. | EVP, Chief Human Resources Ofc | Non-Qualified Stock Option (right to buy) | Disposal | 6,000 | 0 |
| Oct 14, 2025 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Non-Qualified Stock Option (right to buy) | Disposal | 11,475 | 0 |
| Oct 14, 2025 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Disposal | 11,475 | 72.034 |
| Oct 14, 2025 | BIRCHLER, BRIAN | EVP, Corp and Development Ops | Common Stock | Acquisition | 11,475 | 53.77 |
| Oct 6, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Non-Qualified Stock Option (right to buy) | Disposal | 10,200 | 0 |
| Oct 6, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 3,241 | 69.265 |
| Oct 6, 2025 | MONIA, BRETT P | Director, Chief Executive Officer | Common Stock | Disposal | 437 | 69.264 |
| Oct 6, 2025 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 6,849 | 69.02 |
| Oct 6, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 10,200 | 52.87 |
| Oct 6, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 10,200 | 69.887 |
| Oct 6, 2025 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 1,625 | 69.369 |
| Oct 6, 2025 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 1,625 | 69.369 |
| Oct 2, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Non-Qualified Stock Option (right to buy) | Disposal | 30,203 | 0 |
| Oct 2, 2025 | SWAYZE, ERIC | EVP Research | Non-Qualified Stock Option (right to buy) | Disposal | 12,972 | 0 |
| Oct 2, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 30,203 | 67.689 |
| Oct 2, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Non-Qualified Stock Option (right to buy) | Disposal | 34,461 | 0 |
| Oct 2, 2025 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Disposal | 15,000 | 68.014 |
| Oct 2, 2025 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Common Stock | Acquisition | 15,000 | 31.8 |
| Oct 2, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 30,203 | 56.78 |
| Oct 2, 2025 | BAROLDI, JOSEPH | EVP, Chief Business Officer | Non-Qualified Stock Option (right to buy) | Disposal | 15,000 | 0 |
| Oct 2, 2025 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 12,972 | 66.226 |
| Oct 2, 2025 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 12,972 | 53.77 |
| Oct 2, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 34,461 | 60.89 |
| Oct 2, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 34,461 | 67.689 |
| Oct 1, 2025 | SWAYZE, ERIC | EVP Research | Non-Qualified Stock Option (right to buy) | Disposal | 14,142 | 0 |
| Oct 1, 2025 | SWAYZE, ERIC | EVP Research | Common Stock | Acquisition | 14,142 | 53.77 |
| Oct 1, 2025 | SWAYZE, ERIC | EVP Research | Common Stock | Disposal | 14,142 | 66.091 |
| Oct 1, 2025 | WENDER, JOSEPH H | Director | Common Stock | Disposal | 16,800 | 65.499 |
| Sep 30, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 14,827 | 56.78 |
| Sep 30, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 14,827 | 64.678 |
| Sep 30, 2025 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Acquisition | 49,800 | 53.77 |
| Sep 30, 2025 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Common Stock | Disposal | 49,800 | 65.256 |
| Sep 30, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Non-Qualified Stock Option (right to buy) | Disposal | 14,827 | 0 |
| Sep 30, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Disposal | 57,900 | 65.245 |
| Sep 30, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Common Stock | Acquisition | 57,900 | 53.77 |
| Sep 30, 2025 | GEARY, RICHARD S | EVP, Chief Development Officer | Non-Qualified Stock Option (right to buy) | Disposal | 57,900 | 0 |
| Sep 30, 2025 | HOUGEN, ELIZABETH L | EVP, Finance & CFO | Non-Qualified Stock Option (right to buy) | Disposal | 49,800 | 0 |
| Sep 29, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Acquisition | 10,473 | 56.78 |
| Sep 29, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Common Stock | Disposal | 10,473 | 64.542 |
| Sep 29, 2025 | O'NEIL, PATRICK R. | EVP CLO & General Counsel | Non-Qualified Stock Option (right to buy) | Disposal | 10,473 | 0 |